With aesthetic medicine constantly evolving, non-invasive treatments are becoming more sought after by those who desire cosmetic treatment, giving them a natural enhancement.
Some of these are PRP (Platelet-rich plasma) therapy and polynucleotide treatments, which offer highly effective regenerative capacity with the most natural results. Each of these treatments is known for its skin-revitalising properties and healing capabilities due to its anti-ageing benefits. Still, as with any medical procedure, there will always be potential risks.
In this article, you will explore the combined benefits and potential limitations of these therapies, assisting you in deciding if PRP or polynucleotides are going to align with your aesthetic goals.
What are PRP and Polynucleotides?
PRP therapy is done by drawing a small amount of the patient’s blood and using that to isolate platelets in a centrifuge machine. Within these platelets contain growth factors to enhance tissue repair and collagen production at the site(s) of healing. If PRP is injected directly into the skin or onto our scalp, it speeds up cell turnover, thereby offering benefits in cosmetic rejuvenation and hair restoration. This treatment uses autologous blood from the patient so the chances of an allergic reaction are rare and it will give a natural result.
With a focus on cellular repair and rejuvenation, polynucleotide treatments rely upon synthetic or bio-derived DNA fragments. Polynucleotides act as a structural support for your tissues by activating fibroblasts (the production house for collagen), increasing hydration, and skin elasticity. They are commonly used in anti-ageing applications, especially among those focused on increasing skin elasticity and reducing fine lines. Polynucleotides also contain anti-inflammatory properties, so they are a good option for use on slightly sensitive or irritated skin.
Both PRP and polynucleotide treatments harness the body’s natural healing/collagen to enhance skin health and rejuvenation. They are non-surgical, minimally invasive procedures with little downtime, appealing to those seeking subtle cosmetic improvements. Both stimulate collagen production, improving skin texture, elasticity, and tone, and can complement treatments like microneedling or dermal fillers. Generally well-tolerated, these treatments carry minor risks, such as swelling or redness, and require multiple sessions to achieve optimal anti-ageing results by promoting tissue repair.
Here’s a glance at the current indications in aesthetic medicine:
| Indication | PRP Therapy | Polynucleotide Treatment |
| Facial Rejuvenation | Stimulates collagen production to reduce fine lines and wrinkles | Improves skin elasticity and firmness |
| Skin Hydration | Enhances moisture retention through collagen stimulation | Deeply hydrates the skin by increasing moisture levels |
| Acne Scarring | Helps reduce the appearance of acne scars by promoting tissue regeneration | Smooths skin texture and reduces scarring with anti-inflammatory effects |
| Under-Eye Rejuvenation | Reduces dark circles and puffiness | Tightens and firms sagging skin in the under-eye area |
| Hair Loss (Androgenic Alopecia) | Stimulates hair follicle growth and slows hair loss | May improve scalp health and enhance follicle vitality |
| Post-Procedure Healing | Speeds up recovery when combined with microneedling or laser treatments | Reduces redness and promotes faster healing post-laser or peel treatments |
| Stretch Marks | Improves the appearance of stretch marks by promoting skin regeneration | Improves elasticity and reduces the appearance of early stretch marks |
| Sun Damage and Pigmentation | Repairs sun-damaged skin by encouraging new cell growth | Brightens the skin and reduces mild pigmentation issues |
| Neck and Décolletage Treatment | Improves skin laxity and reduces fine lines in delicate areas | Enhances elasticity and hydration in the neck and chest region |
| Fine Lines & Wrinkles | Reduces wrinkles by stimulating collagen production | Restores firmness and reduces the depth of wrinkles |
| Sensitive or Inflamed Skin | Can be used cautiously to avoid irritation | Ideal for sensitive skin due to anti-inflammatory properties |
| Scalp Health Improvement | Improves blood circulation and follicle health | Supports scalp hydration and soothes irritation |
| Lip Rejuvenation | Enhances volume and smoothness of lips | Improves lip hydration and reduces fine lines |
Note: Indications depend on the patient’s existing condition, and results may vary based on the number of sessions required. Consult with your healthcare professional prior to treatment.
Benefits of PRP and Polynucleotide Treatments
For those interested in natural enhancements without going under the knife, both aesthetic treatments enhance the texture and tone of the skin by generating collagen and smoothing fine lines, acne scars, etc. Furthermore, it enhances aesthetic treatment efficacy by combining PRP/Polynucleotides onto certain treatments such as microneedling and/or laser to reduce downtime. What many patients love about PRP and/or polynucleotide is the natural results they offer, which develop slowly. Over time, you can expect skin improvements to appear naturally.
Specific to polynucleotides, however, they have impressive skin elasticity and hydration-improving abilities. With age, our skin starts to lose its ability to retain moisture and, thus, tends to dry up and begin sagging. Polynucleotide injections help to regain moisture by creating an environment within the skin to trap more nutrients and water. As a bonus to their anti-ageing effects, polynucleotides also provide natural anti-inflammatory benefits to soothe and calm the skin while reducing redness! This makes them safe for people with sensitive skin or those who have recently had laser treatments.
Overall, both treatments are very versatile and can be customised to suit the needs of each patient. For example, it can be used on the scalp for hair growth or face rejuvenation. Polynucleotides are also great for thin areas susceptible to gravitational skin flaccidity commonly seen around our eyes or lips.
Potential Risks and Complications
PRP and polynucleotide therapies are relatively safe, with a low incidence of adverse effects. The most frequent side effects are pain, redness and or swelling at the site of injection, which tend to disappear within a few hours to days.
Patients with a tendency to bruise easily or consume blood thinners might have some mild, transient bruises. If the necessary hygiene or manufacturer protocols are not followed properly, the risk of infection is always a potential result. Some patients may feel itchy or have tenderness at the site of the application after treatment, although those are only short-term side effects in some situations.
The great thing about polynucleotide treatments is that they are not likely to cause an allergic reaction, although in very rare cases, patients may experience adverse systemic responses such as anaphylaxis. Your practitioner will need to inform you about the warning signs properly before treatment to check for any allergies or contraindications. Granulomas or hard lumps are also noted, although this is an unusual side effect where tiny nodules form at the injection site. These conditions are often able to be softened with steroid infusions or oral corticosteroids.
Most reported long-term complications carry a low risk but results and individual patient experiences vary. Patients should set and understand realistic expectations as well as voice up any concerns to the practitioner prior to treatment.
How To Decide If PRP Or Polynucleotides Are The Right One For You
Deciding whether PRP or polynucleotide therapy is right for you requires careful consideration of your aesthetic goals, medical history, and risk tolerance. If you are looking for natural, gradual results to improve skin tone or address hair thinning, PRP might be a suitable option. However, individuals with blood disorders or autoimmune conditions should avoid PRP, as their conditions may interfere with the treatment’s effectiveness.
Polynucleotide treatments may be more appropriate for those seeking to enhance skin hydration and elasticity, especially if they are dealing with dryness, fine lines, or mild sagging. Pregnant or breastfeeding women, however, should avoid polynucleotide injections until after pregnancy due to limited research on the safety of these treatments during that period. Additionally, both treatments require multiple sessions for optimal results, so patients should be prepared to commit to a treatment plan spanning several months.
During your consultation, ask your provider about their experience with these treatments and whether they have treated patients with similar conditions to yours. Inquire about what you can realistically expect from the procedure and whether the treatment plan aligns with your goals.
Here are a few suggested questions to ask your practitioner during the consultation:
- Have you treated patients with conditions similar to mine?
- What kind of results can I realistically expect?
- How soon will I start seeing improvements, and how long will the results last?
- How many sessions will I need for optimal results?
- Is there a specific timeline for follow-ups or maintenance treatments?
- What are the potential risks and side effects?
- How often do complications occur, and how do you handle them if they arise?
- Does this treatment align with my personal aesthetic goals?
- Are there any complementary treatments you recommend to enhance results?
- What preparation is required before the procedure?
- Are there any lifestyle changes or medications I should avoid beforehand?
- What aftercare is needed post-treatment?
- How should I care for the treated area, and are there any restrictions I need to follow?
Choosing the Right Practitioner
Selecting a qualified practitioner is essential for ensuring safe and effective results. Look for a practitioner with specialised training in PRP and polynucleotide therapies, as these treatments require skilful technique and experience.
A reputable clinic will follow strict hygiene protocols to minimise the risk of infections and other complications. Additionally, reading patient reviews and testimonials can provide valuable insight into the clinic’s quality of service.
During your consultation, pay attention to how the practitioner answers your questions and whether they take the time to understand your concerns. An experienced practitioner will set realistic expectations and provide detailed information about post-treatment care.
Preparing for Injectable Treatments
Proper preparation is essential for achieving the best results and minimising side effects.
Before undergoing PRP or polynucleotide therapy, schedule a consultation with your practitioner to ensure the treatment is suitable for your needs. If you are taking blood thinners, your doctor may advise you to discontinue them temporarily to reduce the risk of bruising. Staying hydrated before the procedure is also important, as it helps ensure your body is well-prepared for treatment.
Following the treatment, you should avoid strenuous activities, alcohol, and direct sun exposure for at least 24 to 48 hours. Most patients experience only mild redness or swelling, which resolves within a few days. However, if you notice persistent swelling, fever, or any signs of infection, contact your healthcare professional immediately.
Conclusion
PRP and polynucleotide treatments offer promising solutions for individuals seeking non-invasive aesthetic enhancements. PRP is particularly effective for skin rejuvenation and hair restoration, providing natural-looking results through the body’s healing mechanisms. Polynucleotides, on the other hand, excel at improving skin elasticity and hydration, making them ideal for anti-ageing treatments. While both therapies are generally safe, they come with potential risks that should be carefully considered before proceeding.
Ultimately, the decision to undergo PRP or polynucleotide therapy should be based on your aesthetic goals, medical history, and comfort with the treatment process. Consulting with a qualified practitioner will help you determine the most suitable option for your needs. With the right preparation and realistic expectations, these treatments can provide satisfying, long-lasting results.
FAQs
1. How long do the results of PRP and polynucleotide treatments last?
Results can last several months, but maintenance sessions are recommended every 6-12 months to sustain the effects.
2. Are these treatments painful?
Mild discomfort during injections is common, but numbing creams can be used to minimise pain.
3. Can these treatments be combined with other aesthetic procedures?
Yes, many patients combine PRP or polynucleotides with microneedling, laser, or dermal fillers for enhanced results.
4. Is there any downtime after the procedure?
Most patients can resume normal activities within 24-48 hours, though some swelling or redness may persist briefly.
